What is epithalon (epitalon)?
Epithalon is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly, from the bioregulator research of the Khavinson group. Structure, origin and the state of the evidence.
- Purity
- ≥99% HPLC
- COA
- per batch
- Strength
- 10 · 50 mg
Epithalon
Epithalon is a synthetic peptide of 4 amino acids, the tetrapeptide Ala-Glu-Asp-Gly from the Khavinson group in Saint Petersburg. Buy Epithalon for laboratory research from PulseChem: 10 or 50 mg of lyophilized powder per vial, ≥99% purity by HPLC and a COA for every batch.
Price range: €39.95 through €129.95 incl. VAT
- Shipping from Europe
- 1–3 working days within Europe
Volume discount
- 1–4 unitsUnit price
- 5–9 units5% off
- 10+ units10% off
Research Use Only. For laboratory research use only (in vitro). Not for human or animal use. The products are not medicines, foods, or cosmetics. They are not intended to diagnose, treat, cure, or prevent any disease. The information on this website has not been evaluated by the EMA, the Romanian National Agency for Medicines and Medical Devices (ANMDMR), or the FDA. Read the RUO policy
How is a solution prepared?
This is how solutions are prepared in the lab.
Step 1 of 8: Disinfect
The stoppers of both vials are wiped with an alcohol swab.
- Disinfect. The stoppers of both vials are wiped with an alcohol swab.
- Draw up. The needle passes through the stopper of the bacteriostatic water and the plunger draws up liquid.
- Transfer. The liquid runs down the inside wall of the vial with powder.
- Mix. The vial is gently swirled until the solution is clear.
- Done. The solution is ready for use in research.
- Take sample. A new needle passes through the stopper and the plunger draws up part of the solution.
- Sample vial. The solution runs through the septum of the screw cap into a sample vial.
- Analyze. The sample vial goes into the autosampler; the instrument measures the solution in vitro.
For laboratory research use only (in vitro). Not for human or animal use.
Molecule
Research area: Cells
- Molecular formula
- C14H22N4O9
- Molecular mass
- 390.35 g/mol
Sequence: H-AEDG-OH
- first residue (N-terminus)
Structure from PubChem, CID 219042. As a 3D conformer computed by PubChem.
The chain of Epithalon
Schematic view of the chain. This is not a measured 3D structure.
Point to an amino acid or use the arrow keys to see its name.
Drag or use the arrow keys to rotate the diagram. Point to a bead to see the name of the amino acid.
- Hydrophobic
- Uncharged side chain that avoids water.
- Negatively charged
- Acidic side chain, negative at neutral pH.
- Special (Gly, Pro, Cys)
- Help determine the shape of the chain; cysteine can form a bridge.
The chain has 4 amino acids, shown here from the N-terminus to the C-terminus. Calculated average molecular mass: 390.4 g/mol. Compare this figure with the mass on the certificate of analysis.
On the research map: Cells and mitochondria
Batch and COA
The batch number is on the vial label. You can find the certificate of analysis for that batch on the Lab results page or request it from us.
Specifications
| Contents | 10 mg / 50 mg per vial |
|---|---|
| Sequence | H-Ala-Glu-Asp-Gly-OH |
| Purity | ≥99% (HPLC) |
| Intended use | For laboratory research use only (RUO) |
About Epithalon
Buy Epithalon from PulseChem
Epithalon comes in two strengths: a sealed glass vial with 10 mg or with 50 mg of lyophilized (freeze-dried) powder, from €39.95. Each label shows the strength and the batch number, which leads to the certificate of analysis for that batch.
PulseChem has research peptides for sale to guests and account holders. Anyone aged 18 or over who is buying for laboratory research can order; you confirm research use at checkout.
What is Epithalon?
Epithalon is a tetrapeptide that was designed rather than isolated from a natural source. According to a 2025 overview article in the International Journal of Molecular Sciences, it was synthesized based on the amino acid composition of epithalamin, an extract of the bovine pineal gland. The work comes from the school of Vladimir Khavinson in Saint Petersburg.
Epithalon is not authorized as a medicine. PubChem lists the CAS number 307297-39-8; structure and sources are covered in What is epithalon?
Purity and COA for every batch
An external laboratory measures purity by HPLC (≥99%) and identity by mass spectrometry. Epithalon is small and acidic: in mass spectrometry it falls in the range of salts and fragments, and in HPLC the pH of the mobile phase decides where the peak appears. So check both the number and the method on the COA, via Lab results.
Storage and shipping
Keep the powder in the closed vial, cool, dry and dark, as the label and COA state. We ship from Europe in insulated packaging with tracking, and add a cold pack in warm weather. An order received and paid before 3 p.m. Central European time on a working day is shipped the same day; delivery takes 1–3 working days within Europe. For addresses in the EU only.
For laboratory research only, not for human or animal use.
Questions about Epithalon
Where can I buy Epithalon?
Epithalon is available from PulseChem in this web shop, from €39.95 including VAT for 10 mg; a 50 mg vial is also offered. Epithalon is in stock. Orders received and paid before 3 p.m. Central European time on a working day ship the same day; delivery takes 1–3 working days within Europe. Every batch comes with a COA.
What is in a vial of Epithalon?
A vial of Epithalon contains 10 or 50 mg of synthetic Epithalon as a lyophilized (freeze-dried) powder, sealed in glass. The label states the strength and the batch number. With that number you find the COA for that exact batch on Lab results, with the purity and the mass measurement.
Is Epithalon a medicine?
No, Epithalon is not a medicine and is not authorized as one. Its PubChem record has no drug information: no development phase and no international nonproprietary name. The Epithalon sold by PulseChem is a research chemical, for laboratory research only and not for human or animal use.
Is Epithalon the same as Epitalon?
Yes, Epithalon and the spelling without the h are two names for the same tetrapeptide, Ala-Glu-Asp-Gly (AEDG). PubChem lists both names under one record, CID 219042, together with the variant epithalone. In the PulseChem web shop the product is called Epithalon.
Background from the knowledge base
What are peptides?
A peptide is a short chain of amino acids joined by peptide bonds. How peptides differ from proteins, which peptides occur in nature, and which items in the catalog are not peptides.
What is a COA?
A certificate of analysis tells you what is in a batch and how it was measured. How to read one, and how to check that it belongs to your vial.