What is TB-500?
TB-500 is a trade name for a seven-amino-acid fragment of thymosin beta-4 with an acetyl group at the start. How it differs from the full protein, its structure, and its status.
- Purity
- ≥99% HPLC
- COA
- per batch
- Strength
- 10 mg
TB-500
TB-500 is a synthetic peptide of 7 amino acids, the acetylated fragment 17 to 23 of the much larger protein thymosin beta-4. Buy TB-500 for laboratory research from PulseChem: each vial holds 10 mg of lyophilized powder with ≥99% purity by HPLC, and every batch has a COA.
€44.95 incl. VAT · €37.15 excl. VAT
- Shipping from Europe
- 1–3 working days within Europe
In stock
Volume discount
- 1–4 unitsUnit price€44.95 per unit
- 5–9 units5% off€42.70 per unit
- 10+ units10% off€40.46 per unit
Research Use Only. For laboratory research use only (in vitro). Not for human or animal use. The products are not medicines, foods, or cosmetics. They are not intended to diagnose, treat, cure, or prevent any disease. The information on this website has not been evaluated by the EMA, the Romanian National Agency for Medicines and Medical Devices (ANMDMR), or the FDA. Read the RUO policy
How is a solution prepared?
This is how solutions are prepared in the lab.
Step 1 of 8: Disinfect
The stoppers of both vials are wiped with an alcohol swab.
- Disinfect. The stoppers of both vials are wiped with an alcohol swab.
- Draw up. The needle passes through the stopper of the bacteriostatic water and the plunger draws up liquid.
- Transfer. The liquid runs down the inside wall of the vial with powder.
- Mix. The vial is gently swirled until the solution is clear.
- Done. The solution is ready for use in research.
- Take sample. A new needle passes through the stopper and the plunger draws up part of the solution.
- Sample vial. The solution runs through the septum of the screw cap into a sample vial.
- Analyze. The sample vial goes into the autosampler; the instrument measures the solution in vitro.
For laboratory research use only (in vitro). Not for human or animal use.
Molecule
Research area: Muscles Heart and vessels
- Molecular formula
- C38H68N10O14
- Molecular mass
- 889.0 g/mol
Sequence: Ac-LKKTETQ-OH
- first residue (N-terminus)
- modified residue or group
Structure from PubChem, CID 62707662. Schematic in 3D, not a measured structure.
The chain of TB-500
Schematic view of the chain. This is not a measured 3D structure.
Point to an amino acid or use the arrow keys to see its name.
Drag or use the arrow keys to rotate the diagram. Point to a bead to see the name of the amino acid.
- Hydrophobic
- Uncharged side chain that avoids water.
- Polar
- Uncharged side chain that binds water.
- Positively charged
- Basic side chain, positive at neutral pH.
- Negatively charged
- Acidic side chain, negative at neutral pH.
The chain has 7 amino acids, shown here from the N-terminus to the C-terminus. The N-terminus is acetylated. Calculated average molecular mass: 889.0 g/mol. Compare this figure with the mass on the certificate of analysis.
On the research map: Muscles, tendons, and repair Heart and blood vessels
Batch and COA
The batch number is on the vial label. You can find the certificate of analysis for that batch on the Lab results page or request it from us.
Specifications
| Contents | 10 mg per vial |
|---|---|
| Sequence | Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln-OH |
| Purity | ≥99% (HPLC) |
| Intended use | For laboratory research use only (RUO) |
About TB-500
Buy TB-500 from PulseChem
A vial of TB-500 contains 10 mg of lyophilized (freeze-dried) powder, sealed in glass. The label carries the batch number, and the same number appears on that batch's COA.
You will find TB-500 for sale here in one strength, 10 mg, and no account is required. Anyone aged 18 or over who is buying for laboratory research can order as a guest or with an account and confirms research use at checkout.
A fragment, not the full protein
TB-500 is a trade name. PubChem and the FDA substance registry link it to the N-terminally acetylated fragment 17 to 23 of thymosin beta-4. The full protein has 43 amino acids; Low, Hu and Goldstein published its sequence in PNAS in 1981, determined on protein from calf thymus. TB-500 is built synthetically rather than extracted from tissue. It is not authorized as a medicine. More in What is TB-500?
Purity and COA for every batch
An external laboratory measures purity by HPLC (≥99%) and identity by mass spectrometry. For TB-500, mass is the deciding check: the fragment is more than five times lighter than full thymosin beta-4, so the COA shows which of the two a batch contains. Look up the batch number on Lab results.
Storage and shipping
Store the closed vial cool, dry and dark, following the label and COA. Parcels leave from Europe with tracking, in insulated packaging and with a cold pack in warm weather. Paid orders in before 3 p.m. Central European time on a working day go out that day; delivery takes 1–3 working days within Europe. Delivery is limited to the EU.
For laboratory research only, not for human or animal use.
Questions about TB-500
Where can I buy TB-500?
TB-500 is available from PulseChem in this web shop. The 10 mg vial costs €44.95 including VAT, and TB-500 is in stock. Paid orders received before 3 p.m. Central European time on a working day ship the same day, and delivery takes 1–3 working days within Europe. Each batch has its own COA.
How is the purity of TB-500 tested?
The purity of TB-500 is measured per batch by an external laboratory using HPLC, and a batch is released at ≥99%. Mass spectrometry confirms identity, which also shows that the batch is the fragment and not full thymosin beta-4. You can find the COA by batch number on the Lab results page.
How is TB-500 shipped and stored?
TB-500 ships from Europe in insulated packaging with a tracking number, with a cold pack added in warm weather. Delivery takes 1–3 working days within Europe. Once it arrives, keep the closed vial cool, dry and dark, as stated on the label and the COA.
Is TB-500 the same as thymosin beta-4?
No, TB-500 is not the same as thymosin beta-4. TB-500 is a synthetic fragment of 7 amino acids: positions 17 to 23, with an acetyl group at the start, as described by PubChem and the FDA substance registry. Thymosin beta-4 itself has 43 amino acids (UniProt P62328).
Background from the knowledge base
What are peptides?
A peptide is a short chain of amino acids joined by peptide bonds. How peptides differ from proteins, which peptides occur in nature, and which items in the catalog are not peptides.
How to read a mass spectrum
A mass spectrum on a certificate of analysis shows m/z, not mass. On ionisation, charge states, monoisotopic and average mass, and peaks that do not belong to the peptide.
