What is a COA?
A certificate of analysis tells you what is in a batch and how it was measured. How to read one, and how to check that it belongs to your vial.
- Purity
- ≥99% HPLC
- COA
- per batch
- Strength
- 10 mg
Thymosin Alpha-1
Thymosin Alpha-1 is a synthetic peptide of 28 amino acids, first isolated from calf thymus tissue and described in 1977. Buy Thymosin Alpha-1 for laboratory research from PulseChem: 10 mg of lyophilized powder per vial, ≥99% purity by HPLC and a COA for every batch.
€67.45 incl. VAT · €55.74 excl. VAT
- Shipping from Europe
- 1–3 working days within Europe
In stock
Volume discount
- 1–4 unitsUnit price€67.45 per unit
- 5–9 units5% off€64.08 per unit
- 10+ units10% off€60.71 per unit
Research Use Only. For laboratory research use only (in vitro). Not for human or animal use. The products are not medicines, foods, or cosmetics. They are not intended to diagnose, treat, cure, or prevent any disease. The information on this website has not been evaluated by the EMA, the Romanian National Agency for Medicines and Medical Devices (ANMDMR), or the FDA. Read the RUO policy
How is a solution prepared?
This is how solutions are prepared in the lab.
Step 1 of 8: Disinfect
The stoppers of both vials are wiped with an alcohol swab.
- Disinfect. The stoppers of both vials are wiped with an alcohol swab.
- Draw up. The needle passes through the stopper of the bacteriostatic water and the plunger draws up liquid.
- Transfer. The liquid runs down the inside wall of the vial with powder.
- Mix. The vial is gently swirled until the solution is clear.
- Done. The solution is ready for use in research.
- Take sample. A new needle passes through the stopper and the plunger draws up part of the solution.
- Sample vial. The solution runs through the septum of the screw cap into a sample vial.
- Analyze. The sample vial goes into the autosampler; the instrument measures the solution in vitro.
For laboratory research use only (in vitro). Not for human or animal use.
Molecule
Research area: Immune
- Molecular formula
- C129H215N33O55
- Molecular mass
- 3,108.3 g/mol
Sequence: Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN-OH
- first residue (N-terminus)
- modified residue or group
Structure from PubChem, CID 16130571. Schematic in 3D, not a measured structure.
The chain of Thymosin Alpha-1
Schematic view of the chain. This is not a measured 3D structure.
Point to an amino acid or use the arrow keys to see its name.
Drag or use the arrow keys to rotate the diagram. Point to a bead to see the name of the amino acid.
- Hydrophobic
- Uncharged side chain that avoids water.
- Polar
- Uncharged side chain that binds water.
- Positively charged
- Basic side chain, positive at neutral pH.
- Negatively charged
- Acidic side chain, negative at neutral pH.
The chain has 28 amino acids, shown here from the N-terminus to the C-terminus. The N-terminus is acetylated. Calculated average molecular mass: 3,108.3 g/mol. Compare this figure with the mass on the certificate of analysis.
On the research map: Immune system
Batch and COA
The batch number is on the vial label. You can find the certificate of analysis for that batch on the Lab results page or request it from us.
Specifications
| Other names | TA-1 |
|---|---|
| Contents | 10 mg per vial |
| Sequence | Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH |
| Purity | ≥99% (HPLC) |
| Intended use | For laboratory research use only (RUO) |
About Thymosin Alpha-1
Buy Thymosin Alpha-1 from PulseChem
The sealed glass vial contains 10 mg of Thymosin Alpha-1 as a lyophilized (freeze-dried) powder. The label carries the batch number, and the same number appears on the certificate of analysis for the batch.
In the literature the peptide is also called TA-1 or thymosin alpha 1. PulseChem has TA-1 for sale to anyone aged 18 or over who is buying for laboratory research, as a guest or with an account. You confirm research use at checkout.
Origin of Thymosin Alpha-1
Allan Goldstein and colleagues isolated Thymosin Alpha-1 from thymosin fraction 5, a preparation from calf thymus, and published its sequence in 1977 in PNAS. The peptide later turned out to be the start of a larger protein, prothymosin alpha.
UniProt (P06454) places Thymosin Alpha-1 at positions 2 to 29 of that protein, with an acetyl group on the first serine. PubChem lists, among others, the CAS number 62304-98-7.
Purity and COA for every batch
An external laboratory measures purity by HPLC (≥99%) and identity by mass spectrometry. For a chain of this length, the spectrum shows several charge states, such as triply and quadruply charged ions near m/z 1037 and 778. The COA for your batch number is on Lab results.
Storage and shipping
Store the vial closed in a cool, dry and dark place, following the label and COA. Parcels ship from Europe in insulated packaging with tracking, with a cold pack added in warm weather. Whatever you order and pay for before 3 p.m. Central European time on a working day, we send the same day; delivery takes 1–3 working days within Europe. EU only.
For laboratory research only, not for human or animal use.
Questions about Thymosin Alpha-1
Where can I buy Thymosin Alpha-1?
Thymosin Alpha-1 is available from PulseChem in this web shop. The 10 mg vial costs €67.45 including VAT, and Thymosin Alpha-1 is in stock. Orders received and paid before 3 p.m. Central European time on a working day go out the same day; delivery takes 1–3 working days within Europe. Every batch has a COA.
What is in a vial of Thymosin Alpha-1?
A vial of Thymosin Alpha-1 contains 10 mg of synthetic peptide as a lyophilized (freeze-dried) powder, sealed in glass. The peptide has 28 amino acids and carries an acetyl group at its start. The label gives the batch number, which you use to look up the COA on Lab results.
How is the purity of Thymosin Alpha-1 tested?
Thymosin Alpha-1 is tested for every batch by an external laboratory: HPLC gives the purity (≥99%), mass spectrometry the identity. For this large peptide, the spectrum shows several charge states that all calculate back to one mass. Both measurements are on the COA of the batch.
Where does Thymosin Alpha-1 come from?
Thymosin Alpha-1 was first isolated from calf thymus tissue; Goldstein and colleagues published its 28-amino-acid sequence in 1977 in PNAS. According to UniProt (P06454), it is the N-terminal segment of the protein prothymosin alpha. The Thymosin Alpha-1 sold by PulseChem is made synthetically, for laboratory research.
Background from the knowledge base
What does 99% purity mean?
A purity of 99% tells you about the composition of the peptide, not about the amount in the vial. What the number measures, and what it does not.
Why lyophilize?
Peptides are supplied as a freeze-dried powder because they break down quickly in solution. What happens during freeze-drying, and what it means for storage.
