What is a COA?
A certificate of analysis tells you what is in a batch and how it was measured. How to read one, and how to check that it belongs to your vial.
- Purity
- ≥99% HPLC
- COA
- per batch
- Strength
- 10 mg
PE-22-28
PE-22-28 is a synthetic peptide of 7 amino acids, a shortened form of spadin, a peptide from the propeptide of sortilin. Buy PE-22-28 for laboratory research from PulseChem: 10 mg of lyophilized powder per vial, ≥99% purity by HPLC and a COA for every batch.
€49.95 incl. VAT · €41.28 excl. VAT
- Shipping from Europe
- 1–3 working days within Europe
In stock
Volume discount
- 1–4 unitsUnit price€49.95 per unit
- 5–9 units5% off€47.45 per unit
- 10+ units10% off€44.96 per unit
Research Use Only. For laboratory research use only (in vitro). Not for human or animal use. The products are not medicines, foods, or cosmetics. They are not intended to diagnose, treat, cure, or prevent any disease. The information on this website has not been evaluated by the EMA, the Romanian National Agency for Medicines and Medical Devices (ANMDMR), or the FDA. Read the RUO policy
How is a solution prepared?
This is how solutions are prepared in the lab.
Step 1 of 8: Disinfect
The stoppers of both vials are wiped with an alcohol swab.
- Disinfect. The stoppers of both vials are wiped with an alcohol swab.
- Draw up. The needle passes through the stopper of the bacteriostatic water and the plunger draws up liquid.
- Transfer. The liquid runs down the inside wall of the vial with powder.
- Mix. The vial is gently swirled until the solution is clear.
- Done. The solution is ready for use in research.
- Take sample. A new needle passes through the stopper and the plunger draws up part of the solution.
- Sample vial. The solution runs through the septum of the screw cap into a sample vial.
- Analyze. The sample vial goes into the autosampler; the instrument measures the solution in vitro.
For laboratory research use only (in vitro). Not for human or animal use.
Molecule
Research area: Brain
- Molecular formula
- C35H55N11O9
- Molecular mass
- 773.9 g/mol
Sequence: H-GVSWGLR-OH
- first residue (N-terminus)
Structure from PubChem, CID 165437303. Schematic in 3D, not a measured structure.
The chain of PE-22-28
Schematic view of the chain. This is not a measured 3D structure.
Point to an amino acid or use the arrow keys to see its name.
Drag or use the arrow keys to rotate the diagram. Point to a bead to see the name of the amino acid.
- Hydrophobic
- Uncharged side chain that avoids water.
- Polar
- Uncharged side chain that binds water.
- Positively charged
- Basic side chain, positive at neutral pH.
- Special (Gly, Pro, Cys)
- Help determine the shape of the chain; cysteine can form a bridge.
The chain has 7 amino acids, shown here from the N-terminus to the C-terminus. Calculated average molecular mass: 773.9 g/mol. Compare this figure with the mass on the certificate of analysis.
On the research map: Brain and pituitary
Batch and COA
The batch number is on the vial label. You can find the certificate of analysis for that batch on the Lab results page or request it from us.
Specifications
| Contents | 10 mg per vial |
|---|---|
| Sequence | H-Gly-Val-Ser-Trp-Gly-Leu-Arg-OH |
| Purity | ≥99% (HPLC) |
| Intended use | For laboratory research use only (RUO) |
About PE-22-28
Buy PE-22-28 from PulseChem
The sealed glass vial contains 10 mg of PE-22-28 as a lyophilized (freeze-dried) powder. The batch number on the label links each vial to the certificate of analysis of its batch.
You can order as a guest or with an account. PE-22-28 for sale at PulseChem is available to anyone aged 18 or over who is buying for laboratory research; you confirm research use at checkout.
What is PE-22-28?
PE-22-28 is a heptapeptide derived from spadin. Mazella and colleagues described spadin in 2010 in PLoS Biology as a 17-amino-acid peptide from the propeptide of sortilin. That propeptide (PE) has 44 amino acids, and spadin covers positions 12 to 28.
Djillani and colleagues designed the shorter form in 2017 (Frontiers in Pharmacology), based on the breakdown products of spadin in blood. The name PE-22-28 therefore refers to positions 22 to 28 of the propeptide. PubChem lists the CAS number 1801959-12-5.
Purity and COA for every batch
An external laboratory determines purity by HPLC (≥99%); mass spectrometry confirms identity. With electrospray, PE-22-28 can appear as a singly and a doubly charged ion, near m/z 774.4 and 387.7, calculated from the monoisotopic mass in PubChem. The COA for your batch is on Lab results.
Storage and shipping
Keep the vial closed, cool, dry and dark; the label and COA give the details. Parcels are shipped from Europe in insulated packaging with tracking, with a cold pack in warm weather. Orders received and paid before 3 p.m. Central European time on a working day ship the same day; delivery takes 1–3 working days within Europe. We deliver within the EU only.
For laboratory research only, not for human or animal use.
Questions about PE-22-28
Where can I buy PE-22-28?
PE-22-28 is available from PulseChem in this web shop. The 10 mg vial costs €49.95 including VAT, and PE-22-28 is in stock. What is ordered and paid before 3 p.m. Central European time on a working day leaves the same day; delivery takes 1–3 working days within Europe. There is a COA for every batch.
How is the purity of PE-22-28 tested?
The purity of PE-22-28 is measured for every batch by an external laboratory using HPLC; a batch is released at ≥99%. Mass spectrometry checks that the measured mass matches the sequence. Both measurements are on the COA, which you find by batch number on Lab results.
Who can order PE-22-28?
PE-22-28 can be ordered by anyone aged 18 or over who is buying for laboratory research. You do not need an account: the research peptides for sale at PulseChem can also be ordered as a guest. At checkout you confirm that the product is for laboratory research only. Organizations can also apply for a business account.
Where does PE-22-28 come from?
PE-22-28 is a shortened form of spadin, a 17-amino-acid peptide from the propeptide of sortilin (Mazella and colleagues, PLoS Biology, 2010). Djillani and colleagues described the shorter seven-amino-acid form in 2017 in Frontiers in Pharmacology. The PE-22-28 sold by PulseChem is synthetic and intended for laboratory research.
Background from the knowledge base
What does 99% purity mean?
A purity of 99% tells you about the composition of the peptide, not about the amount in the vial. What the number measures, and what it does not.
Why lyophilize?
Peptides are supplied as a freeze-dried powder because they break down quickly in solution. What happens during freeze-drying, and what it means for storage.
