What is MOTS-c?
MOTS-c is a peptide of sixteen amino acids encoded not in the cell nucleus but in mitochondrial DNA. Structure, its discovery in 2015, and the state of the research.
- Purity
- ≥99% HPLC
- COA
- per batch
- Strength
- 10 · 40 mg
MOTS-c
MOTS-c is a synthetic peptide of 16 amino acids with the sequence of a peptide encoded in mitochondrial DNA rather than in the cell nucleus. Buy MOTS-c for laboratory research from PulseChem: 10 or 40 mg of lyophilized powder per vial, ≥99% purity by HPLC and a COA for every batch.
Price range: €36.95 through €101.95 incl. VAT
- Shipping from Europe
- 1–3 working days within Europe
Volume discount
- 1–4 unitsUnit price
- 5–9 units5% off
- 10+ units10% off
Research Use Only. For laboratory research use only (in vitro). Not for human or animal use. The products are not medicines, foods, or cosmetics. They are not intended to diagnose, treat, cure, or prevent any disease. The information on this website has not been evaluated by the EMA, the Romanian National Agency for Medicines and Medical Devices (ANMDMR), or the FDA. Read the RUO policy
How is a solution prepared?
This is how solutions are prepared in the lab.
Step 1 of 8: Disinfect
The stoppers of both vials are wiped with an alcohol swab.
- Disinfect. The stoppers of both vials are wiped with an alcohol swab.
- Draw up. The needle passes through the stopper of the bacteriostatic water and the plunger draws up liquid.
- Transfer. The liquid runs down the inside wall of the vial with powder.
- Mix. The vial is gently swirled until the solution is clear.
- Done. The solution is ready for use in research.
- Take sample. A new needle passes through the stopper and the plunger draws up part of the solution.
- Sample vial. The solution runs through the septum of the screw cap into a sample vial.
- Analyze. The sample vial goes into the autosampler; the instrument measures the solution in vitro.
For laboratory research use only (in vitro). Not for human or animal use.
Molecule
Research area: Cells
- Molecular formula
- C101H152N28O22S2
- Molecular mass
- 2,174.6 g/mol
Sequence: H-MRWQEMGYIFYPRKLR-OH
- first residue (N-terminus)
Structure from PubChem, CID 146675088. Schematic in 3D, not a measured structure.
The chain of MOTS-c
Schematic view of the chain. This is not a measured 3D structure.
Point to an amino acid or use the arrow keys to see its name.
Drag or use the arrow keys to rotate the diagram. Point to a bead to see the name of the amino acid.
- Hydrophobic
- Uncharged side chain that avoids water.
- Polar
- Uncharged side chain that binds water.
- Positively charged
- Basic side chain, positive at neutral pH.
- Negatively charged
- Acidic side chain, negative at neutral pH.
- Special (Gly, Pro, Cys)
- Help determine the shape of the chain; cysteine can form a bridge.
The chain has 16 amino acids, shown here from the N-terminus to the C-terminus. Calculated average molecular mass: 2,174.6 g/mol. Compare this figure with the mass on the certificate of analysis.
On the research map: Cells and mitochondria
Batch and COA
The batch number is on the vial label. You can find the certificate of analysis for that batch on the Lab results page or request it from us.
Specifications
| Contents | 10 mg / 40 mg per vial |
|---|---|
| Sequence | H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH |
| Purity | ≥99% (HPLC) |
| Intended use | For laboratory research use only (RUO) |
About MOTS-c
Buy MOTS-c from PulseChem
MOTS-c for sale at PulseChem comes as 10 mg or 40 mg per vial. Each sealed glass vial holds the peptide as lyophilized powder, with the strength and batch number on the label. Prices start at €36.95.
You order as a guest or with an account, from age 18 and for laboratory research. You confirm that research use at checkout.
Origin in mitochondrial DNA
Almost every peptide in a cell is encoded in the DNA of the nucleus; MOTS-c is not. Lee and colleagues described it in 2015 in Cell Metabolism. They found a short open reading frame of 51 base pairs in the gene for the 12S ribosomal RNA of the mitochondrion. According to the authors, the peptide is made outside the mitochondrion, using the standard genetic code.
This places MOTS-c among the mitochondrial-derived peptides. Its CAS number is 1627580-64-6. MOTS-c is not authorized as a medicine. More in What is MOTS-c?
Purity and COA for every batch
Every batch of MOTS-c is analyzed externally: HPLC for purity (≥99%) and mass spectrometry for identity. Three arginines and a lysine make the peptide strongly basic, so with electrospray ionization the spectrum shows several charge states. Oxidation of one of the two methionines would appear as a separate peak about 16 units higher. Find the COA by batch number on Lab results.
Storage and shipping
Methionine is sensitive to oxidation, so keep the vial closed, cool, dry and dark following the label and COA. Your parcel travels insulated and tracked, with a cold pack in warm weather. We ship from Europe to the EU; delivery takes 1–3 working days within Europe. Orders received and paid before 3 p.m. Central European time on a working day still ship the same day.
For laboratory research only, not for human or animal use.
Questions about MOTS-c
Where can I buy MOTS-c?
MOTS-c is available from PulseChem in this web shop. Prices start at €36.95 including VAT for 10 mg, and MOTS-c is in stock. Anything received and paid before 3 p.m. Central European time on a working day ships the same day; delivery takes 1–3 working days within Europe. Every batch has a COA.
Which strengths of MOTS-c are available?
MOTS-c comes in two strengths: 10 mg and 40 mg per vial, both as lyophilized powder in a sealed glass vial. This page shows the current price including VAT for each strength. The batch number on the label leads to the COA for your batch.
How is the purity of MOTS-c tested?
The purity of MOTS-c is determined for every batch by an external laboratory using HPLC, and only a batch at ≥99% is released. Mass spectrometry confirms identity by comparing the measured mass with the calculated mass of MOTS-c. Look up the COA with the batch number on Lab results.
Where does the name MOTS-c come from?
MOTS-c stands for mitochondrial open reading frame of the 12S rRNA-c. Lee and colleagues gave the peptide this name in 2015 in Cell Metabolism, because its code lies in the gene for the 12S ribosomal RNA of the mitochondrion. It is a short open reading frame of 51 base pairs.
Background from the knowledge base
What are peptides?
A peptide is a short chain of amino acids joined by peptide bonds. How peptides differ from proteins, which peptides occur in nature, and which items in the catalog are not peptides.
Storing peptides in the lab
Which chemical reactions make a peptide degrade, which amino acids are sensitive to them, and how to handle temperature, moisture, light and record keeping in the lab.
