What is SS-31 (elamipretide)?
SS-31 is a synthetic tetrapeptide that binds cardiolipin, a lipid in the inner mitochondrial membrane. Structure, origin, and how the medicine differs from research material.
- Purity
- ≥99% HPLC
- COA
- per batch
- Strength
- 10 · 30 mg
SS-31
SS-31 is a synthetic peptide of 4 amino acids from the series of Szeto-Schiller peptides. Buy SS-31 for laboratory research from PulseChem: 10 or 30 mg of lyophilized powder per vial, ≥99% purity by HPLC and a COA for every batch.
Price range: €57.45 through €132.45 incl. VAT
- Shipping from Europe
- 1–3 working days within Europe
Volume discount
- 1–4 unitsUnit price
- 5–9 units5% off
- 10+ units10% off
Research Use Only. For laboratory research use only (in vitro). Not for human or animal use. The products are not medicines, foods, or cosmetics. They are not intended to diagnose, treat, cure, or prevent any disease. The information on this website has not been evaluated by the EMA, the Romanian National Agency for Medicines and Medical Devices (ANMDMR), or the FDA. Read the RUO policy
How is a solution prepared?
This is how solutions are prepared in the lab.
Step 1 of 8: Disinfect
The stoppers of both vials are wiped with an alcohol swab.
- Disinfect. The stoppers of both vials are wiped with an alcohol swab.
- Draw up. The needle passes through the stopper of the bacteriostatic water and the plunger draws up liquid.
- Transfer. The liquid runs down the inside wall of the vial with powder.
- Mix. The vial is gently swirled until the solution is clear.
- Done. The solution is ready for use in research.
- Take sample. A new needle passes through the stopper and the plunger draws up part of the solution.
- Sample vial. The solution runs through the septum of the screw cap into a sample vial.
- Analyze. The sample vial goes into the autosampler; the instrument measures the solution in vitro.
For laboratory research use only (in vitro). Not for human or animal use.
Molecule
Research area: Cells Heart and vessels
- Molecular formula
- C32H49N9O5
- Molecular mass
- 639.8 g/mol
Sequence: H-[D-Arg][Dmt]KF-NH₂
- first residue (N-terminus)
- modified residue or group
Structure from PubChem, CID 11764719. Schematic in 3D, not a measured structure.
The chain of SS-31
Schematic view of the chain. This is not a measured 3D structure.
Point to an amino acid or use the arrow keys to see its name.
Drag or use the arrow keys to rotate the diagram. Point to a bead to see the name of the amino acid.
- Hydrophobic
- Uncharged side chain that avoids water.
- Polar
- Uncharged side chain that binds water.
- Positively charged
- Basic side chain, positive at neutral pH.
The chain has 4 amino acids, shown here from the N-terminus to the C-terminus. The C-terminus is an amide and 1 building block is in the D-form. Calculated average molecular mass: 639.8 g/mol. Compare this figure with the mass on the certificate of analysis.
On the research map: Cells and mitochondria Heart and blood vessels
Batch and COA
The batch number is on the vial label. You can find the certificate of analysis for that batch on the Lab results page or request it from us.
Specifications
| Contents | 10 mg / 30 mg per vial |
|---|---|
| Sequence | H-D-Arg-Dmt-Lys-Phe-NH2 |
| Purity | ≥99% (HPLC) |
| Intended use | For laboratory research use only (RUO) |
About SS-31
Buy SS-31 from PulseChem
PulseChem offers SS-31 in two strengths: 10 mg and 30 mg per vial. The peptide is supplied as lyophilized powder in a sealed glass vial, with strength and batch number on the label. Prices start at €57.45.
The SS-31 for sale here can be ordered by anyone aged 18 or over who buys for laboratory research, as a guest or with an account. You confirm research use at checkout.
What is SS-31?
The letters SS stand for Szeto-Schiller, after Hazel Szeto (Weill Cornell Medicine, New York) and Peter Schiller (Institut de recherches cliniques de Montréal). Zhao and colleagues, with Szeto and Schiller among the authors, described in 2004 in the Journal of Biological Chemistry how these short peptides enter cells and accumulate in the inner mitochondrial membrane.
SS-31 contains D-arginine and 2',6'-dimethyltyrosine, two building blocks outside the standard set. Its CAS number is 736992-21-5. The SS-31 from PulseChem is a research chemical, not a medicine; the regulatory status is covered in What is SS-31?
Purity and COA for every batch
An external laboratory tests every batch of SS-31 by HPLC for purity (≥99%) and by mass spectrometry for identity. A calculator that only knows the twenty standard amino acids gets the wrong mass for SS-31, because dimethyltyrosine weighs more than tyrosine. The COA for your batch number is on Lab results.
Storage and shipping
Store SS-31 closed, cool, dry and dark, following the label and COA. We ship from Europe in insulated packaging with tracking, with a cold pack when it is warm. Delivery takes 1–3 working days within Europe, and we deliver within the EU only. Anything received and paid before 3 p.m. Central European time on a working day ships the same day.
For laboratory research only, not for human or animal use.
Questions about SS-31
Where can I buy SS-31?
SS-31 is available from PulseChem in this web shop. Prices start at €57.45 including VAT for 10 mg, and SS-31 is in stock. Orders received and paid before 3 p.m. Central European time on a working day ship the same day; delivery takes 1–3 working days within Europe. Every batch has its own COA.
What is in a vial of SS-31?
A vial of SS-31 contains 10 mg or 30 mg of the peptide as lyophilized powder, depending on the strength you choose. The glass vial is sealed, and the strength and batch number are on the label. With that number, you can find the COA for your batch.
Who can order SS-31?
SS-31 can be ordered by anyone aged 18 or over who buys it for laboratory research, as a guest or with an account. At checkout, you confirm that the product is for laboratory research only. PulseChem ships from Europe and delivers within the EU only.
Is SS-31 a medicine?
The SS-31 from PulseChem is a research chemical, not a medicine. In the United States, a medicine with the same active substance has been approved since 2025; that is a finished product from one manufacturer, with its own formulation and oversight. In the EU, there is no marketing authorization. Details are in What is SS-31?
Background from the knowledge base
What are peptides?
A peptide is a short chain of amino acids joined by peptide bonds. How peptides differ from proteins, which peptides occur in nature, and which items in the catalog are not peptides.
What is MOTS-c?
MOTS-c is a peptide of sixteen amino acids encoded not in the cell nucleus but in mitochondrial DNA. Structure, its discovery in 2015, and the state of the research.
